Kyrle Disease - Symptoms, Causes & Treatment
Medically reviewed by Dr. Anand S. Urhekar, MD, MD Pathology, Clinical Advisor · Last updated July 2026
An acquired perforating dermatosis producing crops of firm, itchy papules with a central keratin plug, mainly on the lower legs and trunk. It is strongly associated with chronic kidney disease (particularly patients on dialysis) and diabetes mellitus.
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Quick Answer
Kyrle disease is a perforating skin disorder causing firm itchy bumps with a hard central plug, mostly on the lower legs. It occurs mainly in people with chronic kidney disease on dialysis and in diabetes. Scratching drives new lesions, so itch control is central: emollients, topical steroids or retinoids, phototherapy, and optimising the underlying kidney or diabetes management.
Symptoms
- Firm papules 2–8 mm with a central horny plug
- Itch, often severe
- Lower legs, thighs and trunk
- New lesions along scratch lines
- Scarring and dark marks after resolution
Causes & Risk Factors
- Chronic kidney disease, especially on haemodialysis
- Diabetes mellitus
- Liver disease and hypothyroidism in some cases
- Repeated scratching perpetuating lesions
Treatment & Management
- Optimising treatment of kidney disease or diabetes
- Intensive emollients and itch control
- Topical corticosteroids or retinoids; keratolytics such as urea or salicylic acid
- Narrowband UVB phototherapy
- Oral antihistamines, gabapentin or other agents for uraemic itch
When to See a Doctor
See a doctor about persistent itchy plugged bumps on the legs, particularly if you have kidney disease or diabetes — blood tests for renal and glucose control are part of the assessment.
Frequently Asked Questions
Why does it happen with kidney disease?
Uraemic itch drives repeated scratching, and altered collagen metabolism allows keratin and dermal material to be extruded through the epidermis. Controlling itch and dialysis adequacy is the mainstay.
Will the lesions clear?
Individual lesions resolve over weeks, often leaving marks or small scars, but new crops continue while the itch and the underlying condition persist.
Medical References
Information on this page is sourced from and verified against reputable medical resources:
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Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. The content on this page should not be used to diagnose or treat any health problem. Always consult with a qualified healthcare professional for proper medical evaluation, diagnosis, and treatment of your condition.